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    Drug Interaction Checkers

    Catch dangerous combinations before they hurt.

    Drugs.com Interactions

    FREE

    Best free interaction checker. Type meds, get severity-rated warnings.

    Best free.

    Medscape

    FREE

    Pro-grade tool. Used by doctors. Free with signup.

    Best clinical.

    WebMD Drug Interaction Checker

    FREE

    Familiar UI. Senior-friendly explanations.

    Best for seniors.

    Apple Health Medications

    FREE

    iOS 16+ flags interactions automatically.

    Best built-in.

    GoodRx app

    FREE

    Has interaction checker + price comparison.

    Best with prices.

    Your pharmacist

    FREE

    Best interaction-checker walks behind any counter. ASK.

    Best human.

    Common dangerous interactions

    • Blood thinner (Warfarin/Eliquis) + ibuprofen/aspirin — bleeding risk.
    • Statin + grapefruit — affects metabolism, can be toxic.
    • Antidepressant + St. John's Wort — serotonin syndrome.
    • Multiple anti-anxiety / sleep meds — over-sedation, fall risk.
    • BP medication + decongestants — spike blood pressure.
    • Insulin / diabetes meds + alcohol — dangerous lows.
    • Ginkgo + blood thinners — increased bleeding.

    Don't forget OTC + supplements

    • Aspirin + blood thinners.
    • Tylenol — too much can damage liver, especially with alcohol.
    • Decongestants (Sudafed) — raise blood pressure.
    • Antihistamines (Benadryl) — increase fall risk in seniors.
    • Vitamin K + blood thinners — affects effectiveness.
    • Fish oil + blood thinners — bleeding risk.
    • St. John's Wort — interacts with MANY meds.

    Pharmacist is free + best

    Walk into Walgreens / CVS / Costco. Hand pharmacist your medication list. Ask "any concerning interactions?" Free service. Better than any app. Pharmacists are medication experts AND they have access to your prescription history.